Open knowledge graph on clinical trials

VaidhyaMegha is building an open knowledge graph on clinical trials, comprising

  • Clinical trial ids from across the globe
  • MeSH ids for
    • Symptoms/Phenotype
    • Diseases
  • PubMed Article ids
  • Genotype(from Human Genome),

Specification

Below is a very brief specification

  • Inputs
    • Mesh RDF
    • WHO’s clinical trials database – ICTRP.
    • US clinical trial registrydata from CTTI’s AACT database.
    • Data from clinical trial registries across the globe scraped from their websites’ ex: India
    • MEDLINE Co-Occurrences (MRCOC) Files
  • Outputs
    • Clinical Trials RDF with below constituent ids and their relationships
      • MeSH, Clinical Trial, PubMed Article, Symptom/Phenotype, Genotype(from Human Genome)
      • Additionally, clinical trial -> clinical trial links across trial registries will also be discovered and added.

Source code

  • Source code would be hosted here.

Release notes

v0.2 : 27-Jan-2022

  • Clinical trials are linked to the RDF nodes corresponding to the MeSH terms for conditions.
  • Download the enhanced RDF from here.

Reference

VaidhyaMegha’s prior work on

  • clinical trial registries data linking.
  • symptoms to diseases linking.
  • phenotype to genotype linking.
  • trials to research articles linking.

Last 3 are covered in the examples folder. They were covered in prior work in separate public repos.